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resveratrol’s potential benefits for Diabetics
New Research on Resveratrol show it may have an affect on insulin resistance.
Reseveratrol is found in Grapes however most of the reseratrol taken today iis derived from the dried root and stem of Polygonum cuspidatum refered to as HU Xhang in Chinese medicen.. It has been used traditionally in Chinese and Japanese medicine (Japnese knott weed) as a circulatory tonic. Significant recent attention has focused on the high natural concentration of resveratrol in Hu Zhang. Much research has been done on resveratrol’s ability to help the body address a number of health conditions. Most of the Resveratrol today comes from Polygonum cuspidatum or Hu Zhang.
Our Genenuvax Product for celluar health contains reseratrol from Polygonum cuspidatum (also called japanese Knott weed), as well as othe top anti-oxdiants that provide support to help the body resist oxidative stress using all of the top ingredients.
While more research needs to be done before conclussions can be drawn, One study showed a significant improvement in insulin resistance.
The Hungarian researchers recruited 19 people type-2 diabetics and randomly assigned them to receive either resveratrol supplements (two 5 milligram doses from Argina Nutraceuticals, Hungary) or placebo for four weeks.
Results showed that after four weeks of resveratrol supplementation, the participants showed a significant decrease in insulin resistance, compared to the placebo group.
In terms of a potential mode of action for the polyphenol, the researchers noted that this may be related to its antioxidant activity, because oxidative stress is “widely accepted” as a key driver in the onset of insulin resistance.
There is also the possibility that resveratrol’s potential benefits are linked to its ability to activate Akt phosphorylation - an intracellular insulin dependent protein that facilitates the uptake of glucose into cells. Indeed, an increase in the levels of phosphorylated Akt (activated) to Akt was observed.
“The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway,” concluded the researchers.
Source: British Journal of Nutrition
Published online ahead of print, doi: 10.1017/S0007114511000316
“Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients”
Authors: P Brasnyo, G.A. Molnar, M. Mohas, L. Marko, B. Laczy, J. Cseh, E. Mikolas, I. Andras Szijarto, A. Merei, R. Halmai, L.G. Meszaros, B. Sumegi, I. Wittmann